On-Site Ribosome Remodeling by Locally Synthesized Ribosomal Proteins in Axons
Summary: Ribosome assembly occurs mainly in the nucleolus, yet recent studies have revealed robust enrichment and translation of mRNAs encoding many ribosomal proteins (RPs) in axons, far away from neuronal cell bodies.Here, we report a physical and functional interaction between locally synthesized RPs and ribosomes in the axon.We show that axonal